Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance
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- 作者：Xavier S. Revelo1 ; xrevelo@uhnresearch.ca" class="auth_mail" title="E-mail the corresponding author ; Magar Ghazarian1 ; Melissa Hui Yen Chng2 ; Helen Luck1 ; Justin H. Kim1 ; Kejing Zeng1 ; 3 ; Sally Y. Shi1 ; Sue Tsai1 ; Helena Lei1 ; Justin Kenkel2 ; Chih Long Liu4 ; Stephanie Tangsombatvisit4 ; Hubert Tsui5 ; Corneliu Sima6 ; Changting Xiao7 ; Lei Shen8 ; Xiaoying Li9 ; Tianru Jin1 ; Gary F. Lewis7 ; Minna Woo1 ; 7 ; Paul J. Utz4 ; Michael Glogauer10 ; Edgar Engleman2 ; Shawn Winer1 ; 11 ; 12 ; 14 ; Daniel A. Winer1 ; 5 ; 12 ; 13 ; 14 ; dan.winer@uhn.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：717-730
- 全文大小：2711 K
文摘
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Obesity promotes increased release and decreased clearance of nucleic acid antigens
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Aberrant handling of nucleic acid and related antigens results in autoantibodies
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Excess nucleic acids worsen metabolism through VAT macrophages and liver pDCs
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Inhibiting TLR7/9 improves obesity-related inflammation and glucose homeostasis