Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone
详细信息 查看全文
- 作者：Sze Wah Samuel Chan1 ; 5 ; Jason Yau1 ; 2 ; 5 ; Christopher Ing1 ; 2 ; Kaiyin Liu1 ; Patrick Farber2 ; Amy Won3 ; Vaibhav Bhandari1 ; Nareg Kara-Yacoubian1 ; Thiago V. Seraphim1 ; Nilmadhab Chakrabarti2 ; Lewis E. Kay1 ; 2 ; 4 ; Christopher M. Yip1 ; 3 ; Ré ; gis Pomè ; s1 ; 2 ; Simon Sharpe1 ; 2 ; ssharpe@sickkids.ca" class="auth_mail" title="E-mail the corresponding author ; Walid A. Houry1 ; walid.houry@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：24
- 期：7
- 页码：1095-1109
- 全文大小：4803 K
文摘
- •
Bacterial chaperone ATPase RavA was unexpectedly observed to form an amyloid state
- •
LARA domain of RavA drives amyloidogenesis at low pH and high temperatures
- •
LARA stability and dynamics were studied in detail using NMR and MD simulations
- •
Destabilization of the N-terminal loop of LARA initiates amyloid formation