Novel magnetic-fluorescent CS-Fe₃O₄@ZnS:Mn/ZnS (core/shell) nanoparticles: Preparation, characterization and damage to bovine serum albumin under UV irradiation

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• 作者：Li Liu ^{liuli5058@yahoo.cn} ; Ling Xiao ; ^{775706196@qq.com} ; Chunhua Cao
• 关键词：A. Biomaterials ; A. Magnetic materials ; A. Composite materials ; A. Interfaces
• 刊名：Materials Chemistry and Physics
• 出版年：2013
• 出版时间：15 July, 2013
• 年：2013
• 卷：140
• 期：2-3
• 页码：575-582
• 全文大小：1717 K

文摘

Novel magnetic-fluorescent nanoparticles (CS-Fe₃O₄@ZnS:Mn/ZnS) combined ZnS:Mn/ZnS semiconductor nanoparticles and Fe₃O₄ magnetic nanoparticles with chitosan (CS) matrix were prepared and characterized. Characterization results indicate that CS-Fe₃O₄@ZnS:Mn/ZnS (core/shell) nanoparticles show superparamagnetic and strong fluorescent properties. Introduction of ZnS shell significantly enhances the photoluminescence intensity by 3.5 times. The saturation magnetization of CS-Fe₃O₄@ZnS:Mn/ZnS nanoparticles was 14.85?emu?g^?1 at room temperature. The interaction and damage of CS-Fe₃O₄@ZnS:Mn/ZnS to bovine serum albumin (BSA) under UV irradiation was investigated by ultraviolet-visible and fluorescence spectra. The results show that electrostatic interaction is the major force for the binding processes of BSA to the surface of CS-Fe₃O₄@ZnS:Mn/ZnS. The damage of BSA is prone to happen in the presence of CS-Fe₃O₄@ZnS:Mn/ZnS under UV irradiation. CS-Fe₃O₄@ZnS:Mn/ZnS may be potential candidate for application as photosensitizers in photodynamic therapy, and fluorescence imaging and magnetic resonance imaging contrast agents for theranostics of cancer.