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Optimization and evaluation of MALDI TOF mass spectrometric imaging for quantification of orally dosed octreotide in mouse tissues
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文摘
The quantitative ability of MALDI-TOF-MSI was optimized and evaluated. The LC–MS/MS assay was used to validate the reliability of MALDI-TOF-MSI. MALDI-TOF-MSI was used to visualize the distribution of octreotide in mice. The key pharmacokinetic parameters of octreotide were calculated.

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