Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway
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- 作者：Xiaoyun Jiang ; Liang Zhong ; Dayu Sun ; Lan Rong ; rlan001@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NLRP ; NOD-like receptor protein ; ASC ; apoptosis-associated speck-like protein containing ; DSS ; dextran sodiumsulfate ; TNF-α ; tumor necrosis factor-α ; UC ; Ulcerative colitis ; IBD ; inflammatory bowel diseases ; HE ; hematoxylin and eosin ; TEM ; transmission electronic microscopy ; WB ; Western blot ; IL-1β ; interleukin 1β ; IL-18 ; interleukin 18
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：72-77
- 全文大小：2923 K
文摘
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TNF-α level was increased in acute and chronic colitis groups.
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NLPR3, ASC, caspase-1 protein expressions were increased in colitis groups.
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Magnesium lithospermate B could be used to treat acute and chronic colitis.
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Magnesium lithospermate B inhibited activation of the NLRP3/ASC/Caspase 1.