Recent advances on the encoding and selection methods of DNA-encoded chemical library

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• 作者：Bingbing Shi^a ; ^b ; Yu Zhou^a ; ^b ; Yiran Huang^b ; Jianfu Zhang^b ; Xiaoyu Li^b ; ^{xiaoyuli@hku.hk}
• 关键词：DNA-encoded library ; Drug discovery ; High throughput screening ; Combinatorial chemistry ; Dynamic combinatorial library
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：27
• 期：3
• 页码：361-369
• 全文大小：1744 K
• 卷排序：27

文摘

DNA-encoded chemical library has become an important technology in drug discovery. Library encoding and selection are two of the most important technological aspects. This digest reviews the latest developments on the encoding methods and selection strategies.