A novel role for Nhp6 proteins in histone gene regulation in Saccharomyces cerevisiae

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• 作者：Diletta Durano^a ; ¹ ; ^{dilettadurano@hotmail.it} ; Andrea Lukacs^a ; ¹ ; ^{ander.lukacs@yahoo.it} ; Francesca Di Felice^a ; ^{francesca.difelice@uniroma1.it} ; Gioacchino Micheli^b ; ^{gioacchino.micheli@uniroma1.it} ; Giorgio Camilloni^a ; ^b ; ^c ; ^{giorgio.camilloni@uniroma1.it}
• 关键词：TSS ; transcriptional start site ; MNase ; Micrococcal nuclease ; NTS ; non transcribed spacer
• 刊名：The International Journal of Biochemistry & Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：83
• 期：Complete
• 页码：76-83
• 全文大小：898 K
• 卷排序：83

文摘

Nhp6 proteins negatively regulate histone genes transcription. Nhp6 proteins stabilize TSS surrounding nucleosomes. The absence of Nhp6 proteins leads to reduction of histone translation. Nhp6 repress histone transcription by stabilizing +1 nucleosomes and act as their regulators.