Uptake of non-invasive prenatal testing in Chinese women: money matters

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• 作者：J. Han ; L. Zhen ; M. Pan ; X. Yang ; Y.-M. Ou ; C. Liao ; D.-Z. Li ; ^{lidongzhi2013@aliyun.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Non-invasive prenatal testing ; Aneuploidy ; Prenatal screening ; Informed decision making ; Mainland China
• 刊名：European Journal of Obstetrics & Gynecology and Reproductive Biology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：195
• 期：Complete
• 页码：100-102
• 全文大小：225 K

文摘

To determine the influence of free invasive prenatal testing on the uptake of non-invasive prenatal testing (NIPT).

Study design

Over a 2-year period at a Chinese tertiary prenatal diagnostic unit, women at risk of fetal trisomy were given the option of NIPT or invasive prenatal testing. Invasive prenatal testing was offered free of charge to women with a local Hukou (household registration); however, women without a local Hukou were charged for invasive prenatal testing. Both women with and without a local Hukou were charged for NIPT.

Results

During the first year, 2647 women with a positive trisomy 21 screening test were referred (474 women with a local Hukou and 2173 women without a local Hukou). Only 1.6% of the women with a local Hukou underwent NIPT, while this proportion was 20.6% in the women without a local Hukou. During the second year, the price of NIPT was reduced. The total number of women referred was 3047 (502 women with a local Hukou and 2545 women without a local Hukou). The uptake of NIPT in women without a local Hukou doubled, but the uptake of NIPT remained stable in women with a local Hukou.

Conclusion

The financial impact on the uptake of NIPT should not be underestimated.