Determination of D-lactide content in lactide stereoisomeric mixture using gas chromatography-polarimetry

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• 作者：Lidong Feng^a ; ^b ; Xinchao Bian^a ; ^b ; Zhiming Chen^b ; Sheng Xiang^a ; ^b ; Yanlong Liu^a ; ^b ; Bin Sun^a ; ^b ; Gao Li^a ; Xuesi Chen^a ; ^{xschen@ciac.ac.cn}
• 关键词：Meso-lactide ; D-lactide ; Gas chromatography ; Polarimetry ; Specific optical rotation ; Error
• 刊名：Talanta
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：164
• 期：Complete
• 页码：268-274
• 全文大小：500 K
• 卷排序：164

文摘

The composition of lactide stereoisomeric mixtures was quantified by GC-Polarimetry. Compared with GC-HPLC, it is suitable to all of lactide samples and more time-saving. The D-lactide content is a function of specific rotation and meso-lactide content. A small amount of impurities in samples little interferes the quantitative analysis. The L-lactide specific rotation is −266.3° (dichloromethane) and −298.8° (toluene).