IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes
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- 作者：Si Ming Man1 ; 7 ; Rajendra Karki1 ; 7 ; Miwa Sasai2 ; David E. Place1 ; Sannula Kesavardhana1 ; Jamshid Temirov3 ; Sharon Frase4 ; Qifan Zhu1 ; 5 ; R.K. Subbarao Malireddi1 ; Teneema Kuriakose1 ; Jennifer L. Peters3 ; Geoffrey Neale6 ; Scott A. Brown1 ; Masahiro Yamamoto2 ; Thirumala-Devi Kanneganti1 ; 8 ; thirumala-devi.kanneganti@stjude.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：innate immunity ; cell-autonomous immunity ; non-canonical inflammasome ; immunity-related GTPases ; GBPs ; GBP2 ; GBP5 ; LPS ; caspase-1 ; interferons
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：382-396.e17
- 全文大小：8596 K
文摘
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IRGB10 is required for activation of multiple inflammasomes by bacteria
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Recruitment of IRGB10 to the bacteria is dependent on GBPs
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IRGB10 targeted bacterial cell membrane and mediated bacterial killing
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IRGB10 liberated ligands and provided a conserved signaling hub for inflammasomes