SAP deficiency mitigated atherosclerotic lesions in ApoE−/− mice
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- 作者：Lingyun Zhengb ; 1 ; Teng Wua ; 1 ; Cuiling Zenga ; Xiangli Lia ; Xiaoqiang Lia ; Dingwen Wena ; Tianxing Jic ; Tian Lana ; Liying Xinga ; Jiangchao Lia ; Xiaodong Hea ; Lijing Wanga ; wanglijing@gdpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Serum amyloid P component ; CD36 ; FcγRI ; MAPK
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：179-187
- 全文大小：2057 K
文摘
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Serum SAP level increased in elderly patients with hyperlipidemia.
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SAP deficiency reduced the plaque size in ApoE−/− mice.
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SAP deficiency partially inhibited macrophage polarization toward M1 or M2 phenotypes and reduced TNF-α, IL-6, RANTES and ICAM1 expression.
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Lack of SAP reduced the plaque size in ApoE−/− mice and foam cell formation by down-regulating CD36/FcγR-dependent pathway.