Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma
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- 作者：Haiyang Zhanga ; Ming Baia ; Ting Denga ; Rui Liua ; Xia Wanga ; Yanjun Qua ; Jingjing Duana ; Le Zhanga ; Tao Ninga ; Shaohua Gea ; Hongli Lia ; Likun Zhoua ; Yuchen Liub ; Dingzhi Huanga ; dingzhih72@163.com" class="auth_mail" title="E-mail the corresponding author ; Guoguang Yinga ; yingguoguang163@163.com" class="auth_mail" title="E-mail the corresponding author ; Yi Baa ; bayi@tjmuch.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microvesicle ; Angiogenesis ; miR-29 ; Gastric cancer ; VEGF
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：375
- 期：2
- 页码：331-339
- 全文大小：3039 K
文摘
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Suppressed expression of miR-29a/c leads to the high levels of VEGF in the gastric tumor microenvironment.
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miR-29a/c regulates VEGF expression by directly targeting the 3′UTR of VEGF mRNA.
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Microvesicles could be used as the nano-particles to transport artificial miRNAs.
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Microvesicle-packed miR-29a/c can be transported in vivo, suppressing angiogenesis in gastric cancer.