A key role for the carboxy-terminal tail of the murine coronavirus nucleocapsid protein in coordination of genome packaging
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- 作者：Lili Kuo ; Cheri A. Koetzner ; Paul S. Masters ; Paul.Masters@health.ny.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Viral genome packaging ; Packaging signal ; RNA virus ; Murine coronavirus ; Mouse hepatitis virus ; Nucleocapsid protein
- 刊名：Virology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：494
- 期：Complete
- 页码：100-107
- 全文大小：1277 K
文摘
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Coronavirus MHV genomic RNA packaging depends on the second RNA-binding domain (CTD) of the nucleocapsid N protein.
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MHV genomic RNA packaging also depends on the carboxy-terminal tail (domain N3) of N protein.
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These findings suggest a mechanism for selective genome packaging, through coupling of genome encapsidation to virion assembly.