MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways
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- 作者：Yanmin Xu ; Ji Huang ; Leina Ma ; Juanjuan Shan ; Junjie Shen ; Zhi Yang ; Limei Liu ; Yongli Luo ; Chao Yao ; Cheng Qian ; cqian8634@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-122 ; IGF-1R ; Sorafenib ; Drug resistance ; Hepatocellular carcinoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 February 2016
- 年：2016
- 卷：371
- 期：2
- 页码：171-181
- 全文大小：3855 K
文摘
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Liver-specific miR-122 expression is significantly reduced in sorafenib-resistant cells.
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Overexpression of miR-122 can confer drug tolerant cells sensitive to sorafenib and induce cell apoptosis.
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Up-regulated of miR-122 mediate cell apoptosis was repressed by IGF-1R activitors and enhanced by IGF-1R inhibitors.
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Up-regulation of IGF-1R contribute to activation of RAS/RAF/ERK signaling which is associated with drug resistance.