SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

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• 作者：Yumiko Oishi¹ ; ² ; ⁹ ; ^{yuooishi-circ@umin.ac.jp} ; Nathanael J. Spann¹ ; ⁹ ; Verena M. Link¹ ; ⁸ ; Evan D. Muse¹ ; ³ ; Tobias Strid¹ ; Chantle Edillor¹ ; Matthew J. Kolar⁴ ; Takashi Matsuzaka⁵ ; Sumio Hayakawa² ; Jenhan Tao¹ ; Minna U. Kaikkonen¹ ; ⁶ ; Aaron F. Carlin¹ ; Michael T. Lam¹ ; Ichiro Manabe⁷ ; Hitoshi Shimano⁵ ; Alan Saghatelian⁴ ; Christopher K. Glass¹ ; ¹⁰ ; ^ckg@ucsd.edu
• 关键词：SREBP1 ; fatty acid metabolism ; lipid metabolism ; inflammation ; innate immunity ; resolution ; unsaturated fatty acids ; transcriptional regulation ; DHA ; EPA
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：412-427
• 全文大小：2858 K
• 卷排序：25

文摘

TLR ligands induce reciprocal inflammatory and lipid biosynthetic gene expression SREBP1 levels and activity are increased 12–24 hr following TLR4 activation SREBP1 drives the production of anti-inflammatory fatty acids in macrophages Loss of SREBP1 results in impaired resolution of inflammatory responses