Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway
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- 作者：Lina Gu ; Xufeng Tao ; Youwei Xu ; Xu Han ; Yan Qi ; Lina Xu ; Lianhong Yin ; Jinyong Peng ; jinyongpeng2014@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSCs ; hepatic stellate cells ; Sirt1 ; Sirtuin 1 ; CCl4 ; carbon tetrachloride ; BDL ; bile duct ligation ; DMN ; dimethylnitrosamine ; HO-1 ; heme oxygenase-1 ; GST ; glutathione-S-transferase ; GCLC ; glutathione cysteine ligase catalytic subunit ; GCLM ; glutathione cysteine ligase modifier subunit ; Nrf2 ; nuclear erythroid factor 2-related factor 2 ; COL1A1 ; collagen α1 (I) ; COL3A1 ; collagen α1 (III) ; a-SMA ; a-smooth muscle actin ; p38 MAPK ; mitogen-activated protein kinase 14 ; siRNA ; small interfering RNA
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：292
- 期：Complete
- 页码：19-29
- 全文大小：3641 K
文摘
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Dioscin showed potent effects against BDL- and DMN-induced liver fibrosis in rats.
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Dioscin significantly suppressed oxidative stress.
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Dioscin triggered Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
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Dioscin should be developed as a novel candidate to treat liver fibrosis.