Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition
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- 作者：Yupeng Hu ; Xufeng Tao ; Xu Han ; Lina Xu ; Lianhong Yin ; Yan Qi ; Yanyan Zhao ; Youwei Xu ; Changyuan Wang ; Jinyong Peng ; jinyongpeng2008@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-oxidative stress ; Dioscin ; Gastric ischemia-reperfusion ; Natural product ; PKC/ERK1/2 signaling pathway
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：234-244
- 全文大小：5455 K
文摘
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Dioscin significantly protected GES-1 cells against I/R injury.
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Dioscin significantly attenuated gastric I/R injury in rats.
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Dioscin attenuated oxidative stress and inflammatory response.
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Dioscin adjusted PKC/ERK1/2 pathway via PKCα and PKCβ2 inhibition.