CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis
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- 作者：Sihem Zitouni1 ; 8 ; zsihem@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author ; Maria E. Francia1 ; 8 ; mfrancia@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author ; Filipe Leal1 ; Susana Montenegro Gouveia1 ; Catarina Nabais1 ; Paulo Duarte1 ; Samuel Gilberto1 ; 10 ; Daniela Brito1 ; Tyler Moyer5 ; Steffi Kandels-Lewis2 ; 3 ; Midori Ohta4 ; Daiju Kitagawa4 ; Andrew J. Holland5 ; Eric Karsenti2 ; 6 ; Thierry Lorca7 ; Mariana Lince-Faria1 ; 9 ; Mó ; nica Bettencourt-Dias1 ; 9 ; mdias@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：PLK4 ; CDK ; STIL ; mitosis ; centriole duplication ; licensing ; centrosome
- 刊名：Current Biology
- 出版年：2016
- 出版时间：9 May 2016
- 年：2016
- 卷：26
- 期：9
- 页码：1127-1137
- 全文大小：3119 K
文摘
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PLK4 activity is needed in G1 for centriole biogenesis
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PLK4 binds its substrate STIL upon inactivation of CDK1-CyclinB
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CDK1-CyclinB binds to STIL in mitosis through the same domain to which PLK4 binds
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CDK1-CyclinB prevents PLK4 from binding and phosphorylating STIL