Expanding the PP2A Interactome by Defining a B56-Specific SLiM

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• 作者：Xinru Wang¹ ; Rakhi Bajaj¹ ; Mathieu Bollen² ; Wolfgang Peti³ ; ⁴ ; Rebecca Page¹ ; ⁵ ; ^{rebecca_page@brown.edu}
• 关键词：PP2A ; B56 ; small linear motif (SLiM) ; BubR1 ; RepoMan ; mitosis ; phosphorylation ; X-ray crystallography ; NMR spectroscopy
• 刊名：Structure
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：24
• 期：12
• 页码：2174-2181
• 全文大小：2560 K
• 卷排序：24

文摘

Crystal structures of PP2A B56 in complex with phosphorylated RepoMan and BubR1 RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions The PP2A-B56 specific short linear motif is L-pS-P-I-x-E The identification of more than 100 proteins that likely bind PP2A via this motif