Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3

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• 作者：Xiaoxia Ren ; Wei Song ; Wenjie Liu ; Xin Guan ; Fei Miao ; Shiying Miao ; Linfang Wang
• 关键词：RHBDD1 ; c-Jun ; Bcl-3 ; Apoptosis
• 刊名：FEBS Letters
• 出版年：2013
• 出版时间：19 June, 2013
• 年：2013
• 卷：587
• 期：12
• 页码：1793-1798
• 全文大小：1060 K

文摘

We have previously reported that rhomboid domain containing 1 (RHBDD1), a new member of the Rhomboid family, is highly expressed in testis. In the present work, luciferase analyses showed that RHBDD1 enhanced the AP-1 activity in a dose- and activity-dependent manner. RHBDD1 overexpression increased c-Jun activity, and the activity was visibly inhibited when RHBDD1 was knocked down. The suppression of c-Jun by inactivation of RHBDD1 was rescued by overexpressing RHBDD1. However, c-Jun overexpression did not alter the expression level of RHBDD1. Furthermore, knockdown of RHBDD1 led to increased cell apoptosis and reduced expression of Bcl-3. Our findings indicate that RHBDD1 could inhibit cell apoptosis by activating and upregulating c-Jun and its downstream target, Bcl-3.