Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
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- 作者：Chao Guo ; Lei Yang ; Jun Luo ; Chao Zhang ; Yuanzheng Xia ; Ting Ma ; Lingyi Kong ; cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SG ; Sophoraflavanone G ; LPS ; lipopolysaccharide ; NO ; nitric oxide ; PGE2 ; prostaglandin E2 ; iNOS ; inducible nitric oxide synthase ; COX-2 ; cyclooxygenase-2 ; TNF-α ; tumor necrosis factor-α ; IL-6 ; interleukin-6 ; IL-1β ; interleukin-1β ; PI3K ; phosphoinositide-3-kinase ; JAK ; Janus kinase ; STAT ; signal transducer and activator of transcription ; PIAS ; protein inhibitor of activated Stat ; HO-1 ; heme oxygenase-1 ; Keap1 ; Kelch-like ECH-associated protein 1 ; Nrf2 ; nuclear factor E2-related factor 2 ; NF-κB ; n
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：349-356
- 全文大小：1181 K
文摘
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SG attenuated LPS-induced production of NO, PGE2, TNF-α, IL-1β and IL-6.
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SG reduced the pro-inflammatory gene expression in protein and mRNA levels.
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SG inhibited the LPS-induced PI3K/Akt activation.
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SG inhibited the LPS-induced JAK/STAT activation.
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SG activated the Nrf2/HO-1 signaling pathway.