Autophagy promoted infectious kidney and spleen necrosis virus replication and decreased infectious virus yields in CPB cell line

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• 作者：Chen Li^a ; ^b ; Xiaozhe Fu^a ; ^c ; Qiang Lin^a ; ^c ; Lihui Liu^a ; ^c ; Hongru Liang^a ; ^c ; Zhibin Huang^a ; Ningqiu Li^a ; ^c ; ^{liningq@126.com}
• 关键词：Siniperca chuatsi ; ISKNV ; Autophagy ; LC3B ; Antiviral response
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：25-32
• 全文大小：1635 K
• 卷排序：60

文摘

Autophagy was triggered by ISKNV infection in CPB cells. ISKNV infection increased the levels of autophagic flux. Induction of autophagy promoted ISKNV replication. Inhibition of autophagy increased extracellular ISKNV yields.