Elevated Hemoglobin Concentration Affects Acute Severe Head Trauma After Recovery from Surgery of Neurologic Function in the Tibetan Plateau

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• 作者：Linjie Wei¹ ; ^{weilinjie8888@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhi Chen² ; Quanhong Xi¹ ; Chaoyuan Wen¹ ; DongPing Ye¹ ; Xin Chen¹ ; Gang Zhu²
• 关键词：Acute severe head trauma ; Elevated hemoglobin concentration group ; Hemoglobin concentration ; Moderate hemoglobin concentration group
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：86
• 期：Complete
• 页码：181-185
• 全文大小：2175 K

文摘

Long-lived inhabitants of the plateau region have a higher hemoglobin concentration, which is the leading cause of damage in various organs, especially the nervous system. The aim of this study was to investigate the effect of hemoglobin concentration on mortality and neural functions after decompressive craniectomy in patients with hypoxia.

Methods

Patients with acute severe head trauma were classified into an elevated hemoglobin concentration group (EHb) and a moderate hemoglobin concentration group (MHb). The survival rate was evaluated by comparing the Glasgow Coma Score on days 1, 3, 7, and 15 after surgery (Kaplan-Meier survival curve). The Glasgow Outcome Scale classification method was used to evaluate recovery of neural function.

Results

The Glasgow Coma Score scores on days 3, 7, and 15 were lower in the EHb group compared with the MHb group (P < 0.05). Mortality was significantly higher in the EHb group compared with the MHb group (P < 0.05). After 6 months, the Glasgow Outcome Scale of the MHb group was significantly higher than that of the EHb group (P < 0.05).

Conclusions

Elevated hemoglobin concentration has a serious impact on neurologic recovery and mortality, as seen in patients with acute severe head trauma after decompressive craniectomy.