The heparin-like activities of negatively charged derivatives of low-molecular-weight polymannuronate and polyguluronate
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- 作者：Quancai Lia ; b ; Yangyang Zenga ; Linlin Wanga ; Huashi Guana ; b ; Chunxia Lia ; b ; lchunxia@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; lichunxiaouc@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Lijuan Zhanga ; c ; lijuanzhang@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polymannuronate ; Polyguluronate ; Polyanionic derivatives ; Heparinoid ; Anticoagulant ; FGFs/FGFR1c signaling
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：313-320
- 全文大小：1545 K
文摘
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LPM and LPG were prepared from alginate and studied side-by-side.
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LPM and LPG derivatives containing −PO32−, −PO2H− and −SO3− were synthesized.
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SO3− modification of LPM and LPG enhanced the anticoagulant and FGFs/FGFR1c signaling activation activities.
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Sulfated LPG had better heparin-like activities than sulfated LPM.