Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells

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• 作者：Tove Ullmark ; Giorgia Montano ; Linnea J&auml ; rvstrå ; t ; Helena Jernmark Nilsson ; Erik Hå ; kansson ; Kristina Drott ; Bjö ; rn Nilsson ; Karina Vidovic ; Urban Gullberg ; ^{urban.gullberg@med.lu.se}
• 关键词：WT1 ; QPRT ; Promoter ; Transcription ; Acute myeloid leukemia ; NAD+
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：802-807
• 全文大小：1024 K
• 卷排序：482

文摘

Wilms’ tumor gene 1 (WT1) acts as a transcriptional activator of quinolinate phosphoribosyltransferase (QPRT). Expression levels of QPRT and WT1 are highly correlated in acute myeloid leukemia. WT1 binds directly to a conserved site in the QPRT promoter.