Increased FNDC5/Irisin expression in human hepatocellular carcinoma

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• 作者：Melania Gaggini^a ; ¹ ; Manuela Cabiati^a ; ¹ ; Serena Del Turco^a ; Teresa Navarra^a ; Paolo De Simone^b ; Franco Filipponi^b ; Silvia Del Ry^a ; Amalia Gastaldelli^a ; Giuseppina Basta^a ; ^{lapina@ifc.cnr.it}
• 关键词：FNDC5 ; fibronectin type III domain containing 5 ; DNL ; de novo lipogenesis ; HCC ; human hepatocellular carcinoma ; SCD-1 ; stearoyl-CoA desaturase ; NOTCH-1 ; Neurogenic locus notch homolog protein 1 ; SREBF-1 ; sterol regulatory element&ndash ; binding factor 1 ; SFA ; saturated fatty acid ; PUFA ; polyunsaturated fatty acid ; CAR ; constitutive androstane receptor ; TNF-α ; tumor necrosis factor-α ; IL-6 ; interleukin-6
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：62-66
• 全文大小：571 K
• 卷排序：88

文摘

Hepatic expression of FNDC5/Irisin mRNA is highly expressed in patients with HCC. There is correlation between FNDC5/Irisin mRNA and key regulators of lipogenesis. There is correlation between FNDC5/Irisin mRNA and inflammatory markers. There is correlation between FNDC5/Irisin mRNA and the oncogene NOTCH1