Effects of treatment with sucrose in drinking water on liver histology, lipogenesis and lipogenic gene expression in rats fed high-fiber diet

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• 作者：Tomislav Ma&scaron ; ek^a ; ^{tomislav.masek@vef.hr} ; Natalija Filipović^b ; Ana Vuica^b ; Kristina Starčević^c
• 关键词：Sucrose ; Cardiolipin ; Phosphatidylethanolamine ; Lipogenesis
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：1-8
• 全文大小：1089 K
• 卷排序：116

文摘

A number of αSMA immunoreactive cells increases in hepatic tissue after long-term sucrose treatment. Long-term sucrose treatment changes fatty acid profile of different phospholipid classes including cardiolipin. Linoleic and linolenic acid concentrations decreases after long-term sucrose treatment. Long-term sucrose treatment decreases phospholipid content of arachidonic acid, but not docosahexaenoic acid. Expressions of Δ5-desaturase and elongase 5 are decreased, while expressions of Δ9-desaturase and SREBP1c are increased after long-term sucrose treatment.