Spectroscopic study on flavonoid-drug interactions: Competitive binding for human serum albumin between three flavonoid compounds and ticagrelor, a new antiplatelet drug
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- 作者：Bing-Mi Liua ; liubingmi@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Zhanga ; Chong-Liang Baib ; Xin Wanga ; Xin-Zhi Qiua ; Xiao-Li Wanga ; Hui Jia ; Bin Liua ; liubinzehao@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavonoid&ndash ; drug interaction ; Ticagrelor ; Human serum albumin ; Competitive binding ; Spectroscopy
- 刊名：Journal of Luminescence
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：168
- 期：Complete
- 页码：69-76
- 全文大小：1849 K
文摘
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Ticagrelor could spontaneously bind in subdomain IIA (site I) on HSA with high affinity.
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The presence of flavonoids could not change the quenching mechanism.
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The presence of flavonoids significantly decreased the binding affinity of ticagrelor with HSA.
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Flavonoids could compete against ticagrelor in site I.
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Baicalin was the most effective competitor among the three flavonoids.