Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva: A qualitative study
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- 作者：Wang Yaoa ; b ; Chen Meic ; Xiao Nanc ; Liu Huia ; liuhui60@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：cfDNA ; cell-free DNA ; STR ; short tandem repeat
- 刊名：Gene
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：590
- 期：1
- 页码：142-148
- 全文大小：486 K
文摘
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DNA degradations were qualitatively observed in serum, saliva and urine.
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DNA degradation followed a first-order clearance model in these samples.
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The half-lives of DNA with protein were relatively longer than those of naked DNA.
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The half-lives were around 3 h in 37 °C and 5 h in 24 °C for serum and saliva.
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The half-lives of DNA in urine were too short to detect in room temperature.