A tyrosinase-triggered oxidative reaction-based “Turn-on” fluorescent probe for imaging in living melanoma cells

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• 作者：Zhipeng Li^a ; ¹Author Vitae ; Yi-Feng Wang^b ; ^c ; ¹Author Vitae ; Xu Zhang^dAuthor Vitae ; Chengchu Zeng^aAuthor Vitae ; Liming Hu^a ; ^e ; ^{huliming@bjut.edu.cn}Author Vitae ; Xing-Jie Liang^b ; ^{liangxj@nanoctr.cn}Author Vitae
• 关键词：Tyrosinase ; Fluorescent probe ; High sensitivity ; Turn-on
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：189-194
• 全文大小：1385 K
• 卷排序：242

文摘

A series of “turn-on” response mechanism compounds (F1-F4) to TYR have been designed and synthesized. Based on tyrosinase-triggered oxidative reaction and urea hydrolysis reaction, F2 have excellent sensitivity and selectivity toward tyrosinase in vitro. F2 was successfully used to imaging living melanoma cells as a result of the conversion of F2 to F0 by TYR catalysis.