Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections

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• 作者：Jolanta Myś ; liwska ; Joanna Wię ; ckiewicz ; Ł ; ukasz Hak ; Janusz Siebert ; Jan Rogowski ; Krzysztof Szyndler ; Andrzej Myś ; liwski
• 关键词：− ; 174G > ; C IL6 polymorphism ; Infections ; CABG ; Complications
• 刊名：International Journal of Cardiology
• 出版年：2007
• 出版时间：12 June 2007
• 年：2007
• 卷：118
• 期：3
• 页码：421-422
• 全文大小：86 K

文摘

We were seeking for a mutual link between the − 174G > C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the − 174G allele carrying patients.