Establishment of quantitative retention-activity model by optimized microemulsion liquid chromatography

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• 作者：Liyuan Xu^a ; ^d ; Haoshi Gao^b ; Liangxing Li^a ; Yinnong Li^a ; Liuyun Wang^a ; Chongkai Gao^c ; Ning Li^a ; ^{13724117338@163.com}
• 关键词：Chromatography ; Microemulsion ; Permeability ; Artificial membrane ; QRAR model
• 刊名：Journal of Chromatography A
• 出版年：2016
• 出版时间：23 December 2016
• 年：2016
• 卷：1478
• 期：Complete
• 页码：10-18
• 全文大小：1464 K
• 卷排序：1478

文摘

The parallel artificial membrane permeability assays model was used to determine the permeability of drugs. The microemulsion composition was adjusted to optimize the system to establish the quantitative retention-activity relationships model. The optimized model was improved by neural networks and support vector machine. MELC is a possible alternative to the PAMPA method for high-throughput permeability determination.