Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen
详细信息 查看全文
- 作者：Isabel Siegert1 ; Johannes Schö ; del2 ; Manfred Nairz3 ; 13 ; Valentin Schatz4 ; Katja Dettmer5 ; Christopher Dick4 ; Joanna Kalucka2 ; 14 ; Kristin Franke6 ; Martin Ehrenschwender4 ; Gunnar Schley2 ; Angelika Beneke7 ; Jö ; rg Sutter8 ; Matthias Moll8 ; Claus Hellerbrand9 ; Ben Wielockx6 ; Dö ; rthe M. Katschinski7 ; Roland Lang1 ; Bruno Galy10 ; Matthias W. Hentze11 ; Peppi Koivunen12 ; Peter J. Oefner5 ; Christian Bogdan1 ; Gü ; nter Weiss3 ; Carsten Willam2 ; Jonathan Jantsch1 ; 4 ; jonathan.jantsch@ukr.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：13
- 期：10
- 页码：2048-2055
- 全文大小：1878 K
文摘
- •
LPS blocks prolyl hydroxylase domain (PHD) enzyme activity and HIF1α degradation
- •
LPS induces ferritin expression and lowers free available iron levels
- •
This results in deprivation of an essential PHD cofactor and HIF1α stabilization