Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss
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- 作者：Tara E. Tracy1 ; 2 ; Peter Dongmin Sohn1 ; 3 ; S. Sakura Minami1 ; 2 ; Chao Wang1 ; 2 ; Sang-Won Min1 ; 2 ; Yaqiao Li1 ; Yungui Zhou1 ; David Le1 ; Iris Lo1 ; Ravikumar Ponnusamy1 ; Xin Cong4 ; Birgit Schilling4 ; Lisa M. Ellerby4 ; Richard L. Huganir5 ; Li Gan1 ; 2 ; 3 ; lgan@gladstone.ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：20 April 2016
- 年：2016
- 卷：90
- 期：2
- 页码：245-260
- 全文大小：5993 K
文摘
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Dementia in AD is marked by enhanced acetylation of K281 and K274 on tau
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Acetylated tau impairs memory encoding and AMPA receptor trafficking during LTP
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Postsynaptic activity-dependent actin polymerization is blocked by acetylated tau
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Loss of postsynaptic protein KIBRA underlies the tau-mediated LTP deficit