Inter-observer variation in delineating the coronary arteries as organs at risk

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• 作者：Anna-Karin Wennstig^a ; ^b ; ^{anakinwen@gmail.com} ; Hans Garmo^c ; ^d ; Per Hå ; llstr&ouml ; m^e ; Petra Witt Nystr&ouml ; m^f ; Per Edlund^e ; Carl Blomqvist^g ; Malin Sund^a ; Greger Nilsson^e ; ^f ; ^h
• 关键词：Breast cancer radiotherapy ; Coronary stenosis ; Delineation ; Inter-observer variation ; Left anterior descending artery
• 刊名：Radiotherapy and Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：122
• 期：1
• 页码：72-78
• 全文大小：592 K
• 卷排序：122

文摘

To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose.MethodDelineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC. Centres of the arteries were calculated and distances between artery centres were measured and the artery radiation doses were estimated. The intraclass correlation coefficient (ICC) was used to quantify the variability in doses.ResultsAlong the extent of RCA, the median distance between centres of arteries varied from 2 to 9 mm with similar patterns over pairs of oncologists. For the LMCA-LAD the median distance varied from 1 to 4 mm. The estimated maximum radiation doses showed an ICC variation from 0.82 to 0.97.ConclusionThe coronary arteries can be reliably identified and delineated as OARs in BC RT. The spatial variance is limited and the total variation in radiation dose is almost completely determined by the between patient variation.