Recipient HLA-C Haplotypes and microRNA 148a/b Binding Sites Have No Impact on Allogeneic Hematopoietic Cell Transplantation Outcomes

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• 作者：Gretchen A. Hoff¹ ; Johannes C. Fischer² ; Katharine Hsu³ ; Sarah Cooley¹ ; Jeffrey S. Miller¹ ; Tao Wang⁴ ; ⁵ ; Michael Haagenson⁶ ; Stephen Spellman⁶ ; Stephanie J. Lee⁷ ; Markus Uhrberg⁸ ; Jeffrey M. Venstrom⁹ ; Michael R. Verneris¹⁰ ; ^{michael.verneris@UCDevnver.edu}
• 关键词：Allogeneic transplant ; HLA-C ; miRNA ; NK cells ; KIR
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：153-160
• 全文大小：734 K
• 卷排序：23

文摘

In contrast to small single-center studies, this large registry study shows that recipients who were homozygous for HLA-C1 epitopes (C1/C1) had no survival benefit. Mismatching at HLA-C was not beneficial in recipients possessing at least 1 C2 allele. The polymorphic microRNA (miR-148a/b) binding site within the 3′-region of the HLA-C, which has been shown to influence HLA-C surface density, is not associated with transplant outcomes.