Genetic association between polymorphisms of Pen2 gene and late onset Alzheimer's disease in the North Chinese population

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• 作者：Longfei Jia ; Jing Ye ; Haiyan L.V. ; Weishan Wang ; Chunkui Zhou ; Xiaojun Zhang ; Jiangtao Xu ; Lingling Wang ; Jianping Jia
• 关键词：Presenilin enhancer 2 ; Apolipoprotein E ; Polymorphism ; Alzheimer's disease
• 刊名：Brain Research
• 出版年：2007
• 出版时间：13 April 2007
• 年：2007
• 卷：1141
• 期：Complete
• 页码：10-14
• 全文大小：163 K

文摘

Presenilin enhancer 2 (Pen2) is a subunit of the gamma-secretase complex which cleaves amyloid precursor protein (APP) to generate amyloid beta (Aβ). We performed a systematic screening of all Pen2 exons and introns using direct sequencing to assess its role in the risk of developing late onset Alzheimer's disease (LOAD). 947 subjects (LOAD: 467; Controls: 480) were recruited for this study. We obtained three polymorphisms: rs10402601, rs3817622, and rs2293688. Among these three polymorphisms, there was an interaction between rs3817622 and apolipoprotein E (APOE) genotypes (P = 0.002). In the subjects with APOE 4 allele, there was a significant difference in the distribution of alleles (P = 0.003) and genotypes (P = 0.007) between LOAD and control groups. ORs [95 % confidence interval (CI)] of allele A and T/A + A/A genotypes were respectively 4.720 (1.517–10.654) and 3.886 (1.381–10.932) with allele T and genotype T/T as a reference. Our results suggest that there is an association between rs3817622 and the development of LOAD in APOE ε4 carriers within the northern Chinese population. It is possible allele A of the Pen2 gene increases the risk for LOAD.