Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880

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• 作者：Mei Han^a ; Rebeca Mejias^a ; Shu-Ling Chiu^b ; Rebecca Rose^a ; Abby Adamczyk^a ; Richard Huganir^b ; Tao Wang^a ; ^{twang9@jhmi.edu}
• 关键词：GRIP1/2 ; glutamate receptor interacting proteins 1 and 2 ; AMPA ; 2-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid ; GluA2 ; AMPA glutamate receptor 2 ; GABAβ3 ; gamma-aminobutyric acid receptor beta 3 subunit
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：176-184
• 全文大小：1452 K
• 卷排序：321

文摘

Neuron-specific Grip1/2-knockout mice show increased social interactions. Increased GluA2-pS880 in frontal cortex and decreased GABAβ3 expression in striatum were identified. Results support a role of Grip1/2-mediated AMPA signaling in regulating social behavior. Disturbances of AMPA- and GABA-signaling are implicated in autism social deficits.