Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation

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• 作者：Enrico Maffini¹ ; ² ; Moreno Festuccia¹ ; ² ; Lucia Brunello¹ ; ² ; Mario Boccadoro¹ ; ² ; Luisa Giaccone¹ ; ² ; Benedetto Bruno¹ ; ² ; ^{benedetto.bruno@unito.it}
• 关键词：Hematopoietic stem cell transplantation ; Central nervous system ; Cyclosporine ; Cerebral aspergillosis ; Viral encephalitis ; Neurological complications
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：388-397
• 全文大小：599 K
• 卷排序：23

文摘

Neurologic complications in hematopoietic stem cell transplantation recipients vary in both incidence and clinical severity. Drug-related toxicities and metabolic alterations represent the most common neurologic complications. Infectious complications include bacterial, fungal, viral, and protozoan pathogens. Opportunistic infections and long-term drug toxicities due to chronic graft-versus-host disease prevention/treatment are the most common causes of late neurologic complications. Post-transplantation lymphoproliferative disorders, disease relapse, and allogeneic HSCT-associated thrombotic microangiopathy are clinical entities to consider in the differential diagnosis.