Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases

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• 作者：Eveline Brodl^a ; Jakov Ivkovic^b ; ¹ ; Chaitanya R. Tabib^a ; Rolf Breinbauer^b ; Peter Macheroux^a ; ^{peter.macheroux@tugraz.at}
• 关键词：DIBALH ; diisobutylaluminum hydride ; DMAP ; 4-(dimethylamino)-pyridine ; DMF ; N ; N-dimethylformamide ; DCM ; dichloromethane ; THF ; tetrahydrofuran
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：25
• 期：4
• 页码：1487-1495
• 全文大小：1725 K
• 卷排序：25

文摘

α,β-unsaturated aldehydes were synthesized in a three-step approach. (Un-)saturated aldehydes were investigated as potential substrates for luciferases. Saturated aldehydes showed higher light emission than unsaturated aldehydes. Light emission increases with longer aldehyde chain length, i.e. C14 > C12 > C10 > C8. Unsaturated aldehydes display slower kinetics of light emission.