The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease
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- 作者：Yeshan Zhua ; zhuyeshan1965@163.com" class="auth_mail" title="E-mail the corresponding author ; Xueqing Lib ; 15531558238@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianquan Chenc ; 741094776@qq.com" class="auth_mail" title="E-mail the corresponding author ; Tongjun Chena ; tongjunchen@sina.com" class="auth_mail" title="E-mail the corresponding author ; Zhimin Shia ; shizhimin0613@163.com" class="auth_mail" title="E-mail the corresponding author ; Miaona Leia ; eimiaona001@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yanjun Zhanga ; zhangyj1312@126.com" class="auth_mail" title="E-mail the corresponding author ; Pengfei Baia ; 854951455@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yifang Lia ; liyifang02@163.com" class="auth_mail" title="E-mail the corresponding author ; Xuan Feia ; 1tsfuyou@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lupeol ; Inflammatory bowel disease ; Macrophages ; Phenotypes ; Cytokines ; Epithelial cells
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：74-84
- 全文大小：1827 K
文摘
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The pentacyclic triterpene Lup-20(29)-en-3β-ol (Lupeol), a potent anti-inflammatory natural product, was able to switch macrophages from M1 to M2 phenotype.
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Moreover, oral administration of Lupeol to dextran sulfate sodium (DSS)-induced colitis mice resulted in mitigated intestinal inflammation and increased survival from lethal colitis, associated with decreased expression of M1-related genes and increased expression of M2-related genes in the lesion.
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Our data suggest Lupeol ameliorates experimental IBD through, at least in part, inhibiting M1 and promoting M2 macrophages.
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Considering the very low toxicity of Lupeol, we believe that these findings are significant.