Microglia response in retina and optic nerve in chronic experimental autoimmune encephalomyelitis
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- 作者：Lioba Horstmanna ; Sandra Kuehna ; Xiomara Pedreiturriab ; Kathrin Haakb ; Christiane Pfarrerc ; H. Burkhard Dicka ; Ingo Kleiterb ; 1 ; Stephanie C. Joachima ; 1 ; stephanie.joachim@rub.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFA ; complete Freund's adjuvant ; EAE ; experimental autoimmune encephalomyelitis ; LFB ; luxol fast blue ; GFAP ; glial fibrillary acid protein ; MOG ; myelin oligodendrocyte glycoprotein ; MS ; multiple sclerosis ; ON ; optic nerve ; PKCα ; protein kinase Cα ; PTx ; pertussis toxin ; RGC ; retinal ganglion cells
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：298
- 期：Complete
- 页码：32-41
- 全文大小：1945 K
文摘
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Brain and optic nerve inflammation remained persistent in chronic EAE.
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A secondary retinal macroglia response occurred 60 days after EAE induction.
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Resting microglia cells increased in retina and optic nerve at late stages of EAE.
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Only ganglion cells are affected in retina at day 60.