Acanthoic acid inhibits LPS-induced inflammatory response by activating LXRα in human umbilical vein endothelial cells
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- 作者：Yong Lia ; Xiao-Shi Zhangb ; Jin-Long Yuc ; yujinlongyl@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acanthoic acid ; Human umbilical vein endothelial cells ; Cytokine ; NF-κB ; LXRα
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：111-115
- 全文大小：698 K
文摘
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Acanthoic acid dose-dependently inhibits LPS-induced IL-8 production.
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Acanthoic acid inhibits LPS-induced VCAM-1 and ICAM-1 expression.
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Acanthoic acid inhibits LPS-induced NF-κB activation.
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The anti-inflammatory effect of acanthoic acid is due to its ability to activate LXRα.