Insights into the development and regulation of T follicular helper cells
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- 作者：Shradha Walia ; b ; 1 ; Anupama Sahooc ; 1 ; Sushant Puria ; Andrei Alekseeva ; Roza Nurievaa ; b ; rnurieva@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Th ; T helper ; Tfh ; T follicular helper ; IL ; interleukin ; Ig ; Immunoglobulin ; STAT ; signal transduction and activator of transcription ; ICOS ; inducible co-stimulator ; SLAM ; signaling lymphocytic activation molecule ; SAP ; slam associated protein ; GC ; germinal center ; Bcl6 ; B cell lymphoma 6 ; SEA ; schistosome egg antigen ; Batf ; basic leucine zipper transcription factor ATF ; BTLA ; B and T-lymphocyte attenuator ; IRF4 ; interferon regulatory factor 4 ; PD-1 ; programmed death-1 ; Blimp-1 ; B lymphocyte-ind
- 刊名：Cytokine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：9-19
- 全文大小：677 K
文摘
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Tfh cells are a distinct T helper lineage that provides help to B cells.
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Tfh cell differentiation is a multistage, multifactorial process with significant heterogeneity.
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Tfh cells can acquire characteristic overlapping with other Th effector cells.
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Tfh cells are a major source of IL-4 which is differentially regulated compared to Th2 cells.
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Tfh cells are implicated in a majority of diseases including immune-mediated disorders.
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