Lymphotoxin-beta receptor expression and its related signaling pathways govern dendritic cell homeostasis and function

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• 作者：Carl De Trez ; ^{carldetrez@yahoo.fr} ; ^{cdetrez@vub.ac.be}
• 关键词：aly ; alymphoplasia ; BTLA ; B and T lymphocyte attenuator ; cDCs ; conventional dendritic cells ; HVEM ; herpesvirus entry mediator ; iDCs ; inflammatory dendritic cells ; LIGHT ; LT-related inducible ligand that competes for glycoprotein D binding to HVEM on T cel
• 刊名：Immunobiology
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：217
• 期：12
• 页码：1250-1258
• 全文大小：759 K

文摘

Dendritic cells (DCs) play a fundamental function, either positive or detrimental, in regulating immune responses. Numerous specialized DC subsets exist in different organs. However, the trophic factors regulating their origin, location, homeostasis and functions remains to be fully understood. Recent evidence indicates that signaling via the lymphotoxin ¦Â receptor (LT¦ÂR) can function as a trophic signaling system for specific DCs. LT¦ÂR is part of a complex signaling network that provides both positive and inhibitory signals to DC subsets. In this review, we focus on the role of LT¦ÂR expressed in DC subsets and its associated signaling pathways that regulate DC homeostasis and function. Therapeutically targeting the LT¦ÂR signaling pathway could support the development of a beneficial immune response for the host.