Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes
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- 作者：Jee Young Kim j.kim@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Xinlai Cheng x.cheng@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Hamed Alborzinia hamed.alborzinia@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Stefan Wö ; lfl ; wolfl@uni-hd.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Jurkat T-cells ; Acidic stress ; Cancer stem cell (CSC) ; Apoptosis ; Alkaline phosphatase (AP)
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：472
- 期：4
- 页码：585-591
- 全文大小：1173 K
文摘
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Sub-lethal acidity of Jurkat T-cells was newly defined with modified STAP protocol.
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Onset of apoptosis (∼8 h) and plummeting cell viability (72 h) were identified.
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T-lymphocytes' responses to acidic stress were irrelevant to OCT4A or OCT4B.
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After the acidic stress, proportion of AP + and PI + populations increased.
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Acidic stress didn't affect CSC or HSC maker expression in Jurkat cells.
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