Chemopreventive effect and lack of genotoxicity and mutagenicity of the exopolysaccharide botryosphaeran on human lymphocytes
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- 作者：M. Malinia ; 1 ; maressa.malini@gmail.com" class="auth_mail" title="E-mail the corresponding author ; M.S. Camargob ; marianasantoro@gmail.com" class="auth_mail" title="E-mail the corresponding author ; L.C. Hernandesc ; livia.hernandes@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; C.G. Vargas-Rechiad ; cvrechia@fcfrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; E.A. Varandab ; eavaranda@gmail.com" class="auth_mail" title="E-mail the corresponding author ; A.M. Barbosae ; 2 ; anelibarbosa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; R.F.H. Dekkere ; rdekker@lakeheadu.ca" class="auth_mail" title="E-mail the corresponding author ; S.T. Matsumotof ; siltamie@gmail.com" class="auth_mail" title="E-mail the corresponding author ; L.M.G. Antunesc ; lusania@fcfrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; I.M.S. Có ; lusa ; ilcecolus@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ames test ; Comet assay ; (1 ; &rarr ; ; 3)(1 ; &rarr ; ; 6)-β-D-glucan ; Jurkat cells ; Human T lymphocytes ; Antigenotoxicity
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：18-25
- 全文大小：480 K
文摘
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The exopolysaccharide botryosphaeran, from B. rhodina, was no mutagenic in bacteria.
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Botryosphaeran not induced genotoxicity in normal and tumor lymphocytes
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Human lymphocytes DNA were protected by botryosphaeran against damage caused by MMS.
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Botryosphaeran was not able to reduce the RONS generated by H2O2.
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Data obtained are important to validation of botryosphaeran as a therapeutic agent.
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