Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease
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- 作者：Katie Richardsona ; 1 ; Achilleas Livieratosa ; 1 ; Richard Dumbilla ; Steven Hughesb ; Gauri Anga ; David A. Smithc ; Lauren Morrisc ; Laurence A. Brownb ; Stuart N. Peirsonb ; Frances M. Plattc ; Kay E. Daviesa ; kay.davies@dpag.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Peter L. Olivera ; peter.oliver@dpag.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lysosome storage disorder ; Ataxia ; Mouse mutant ; Circadian
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：213-223
- 全文大小：3674 K
文摘
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The circadian behaviour of two models of lysosomal storage disorders were examined.
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Npc1 mutant mice show no core circadian defects.
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Hexb knockouts show potential circadian activity disturbances.
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Contrasting pathology in LSDs may differentially contribute to circadian regulation.