Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

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• 作者：Daniel J. Colacurcio^a ; ^b ; ^{DColacurcio@NKI.RFMH.org} ; Ralph A. Nixon^a ; ^b ; ^c ; ^{Nixon@NKI.RFMH.org} ; ^{Ralph.Nixon@nyumc.org} ;
• 关键词：Lysosome ; Acidification ; pH ; v-ATPase ; Endocytosis ; Autophagy ; Lysosomal storage disease ; Alzheimer&rsquo ; s disease ; Parkinson&rsquo ; s disease ; mTORC ; Calcium ; TFEB ; Cathepsin ; Caloric restriction
• 刊名：Ageing Research Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：75-88
• 全文大小：2216 K
• 卷排序：32

文摘

pH regulates hydrolytic, signaling, and homeostatic functions of lysosomes. The v-ATPase complex is mainly responsible for lysosomal acidification. Mutations of v-ATPase components underlie numerous neurodegenerative disorders. Deregulation of lysosomal acidification is implicated in cell aging and longevity. Modulation of lysosomal pH in disease states is a promising therapeutic avenue.