Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice

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• 作者：Schellens ; Jacques P.M. ; Saftig ; Paul ; von Figura ; Kurt ; Everts ; Vincent
• 关键词：Neonatal mice ; M6PR-deficient ; Hepatocytes ; Lysosomes ; Morphometric analysis ; CD-MPR ; cation dependent mannose 6-phosphatereceptor ; CI-MPR ; cation independent mannose 6-phosphate receptor ; IGF II ; insulin-like growth factor II ; M 6-P ; mannose 6-phosphate
• 刊名：Cell Biology International
• 出版年：2003
• 出版时间：November, 2003
• 年：2003
• 卷：27
• 期：1
• 页码：897-902
• 全文大小：393 K

文摘

Transport of lysosomal enzymes is mediated by two mannose 6-phosphate receptors: a cation dependent (CD-MPR) and a cation independent receptor (CI-MPR). In the present study the effect of MPR-deficiency on the lysosomal system of neonatal mouse hepatocytes was studied by ultrastructural morphometric analyses.